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PPAR-alpha (Peroxisome proliferator-activated receptor alpha )

Organism
Danio rerio (Zebrafish)
Phylogeny
Genomic Map Locations
PPAR-alpha1
Dr_Chr.25

PPARalpha-2
DR_Chr.4
Paralogs
Citations
  • Fent K., Chew G., Li J., Gomez E. (2014). Benzotriazole UV-stabilizers and benzotriazole: Antiandrogenic activity in vitro and activation of aryl hydrocarbon receptor pathway in zebrafish eleuthero-embryos. Science of The Total Environment 482-483:125-136. doi:10.1016/j.scitotenv.2014.02.109.
  • Maradonna F., Evangelisti M., Gioacchini G., Migliarini B., Olivotto I., Carnevali O. (2013). Assay of vtg, ERs and PPARs as endpoint for the rapid in vitro screening of the harmful effect of Di-(2-ethylhexyl)-phthalate (DEHP) and phthalic acid (PA) in zebrafish primary hepatocyte cultures. Toxicology In Vitro 27(1):84-91. doi:10.1016/j.tiv.2012.09.018.
  • Craig TA., Zhang Y., McNulty MS., Middha S., Ketha H., Singh RJ., Magis AT., Funk C., Price ND., Ekker SC., Kumar R. (2012). Research resource: whole transcriptome RNA sequencing detects multiple 1alpha,25-dihydroxyvitamin D(3)-sensitive metabolic pathways in developing zebrafish. Molecular Endocrinology 26(9):1630-1642. doi:10.1210/me.2012-1113.
  • Zhang W., Zhang Y., Zhang H., Wang J., Cui R., Dai J. (2012). Sex differences in transcriptional expression of FABPs in zebrafish liver after chronic perfluorononanoic acid exposure. Environmental Science & Technology 46(9):5175-5182. doi:10.1021/es300147w.
  • Avella MA., Place A., Du SJ., Williams E., Silvi S., Zohar Y., Carnevali O. (2012). Lactobacillus rhamnosus accelerates zebrafish backbone calcification and gonadal differentiation through effects on the GnRH and IGF systems. PLoS ONE 7(9):E45572. doi:10.1371/journal.pone.0045572.
  • Zheng D., Kille P., Feeney GP., Cunningham P., Handy RD., Hogstrand C. (2010). Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion. BMC Genomics 11:548. doi:10.1186/1471-2164-11-548.
  • Bertrand S., Thisse B., Tavares R., Sachs L., Chaumot A., Bardet PL., Escriva H., Duffraisse M., Marchand O., Safi R., Thisse C., Laudet V. (2007). Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression. PLoS Genetics 3(11):E188. doi:10.1371/journal.pgen.0030188.
  • McPartland JM., Glass M., Matias I., Norris RW., Kilpatrick CW. (2007). A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio). Molecular Genetics and Genomics 277(5):555-570. doi:10.1007/s00438-007-0207-3.
  • Song HD., Sun XJ., Deng M., Zhang GW., Zhou Y., Wu XY., Sheng Y., Chen Y., Ruan Z., Jiang CL., Fan HY., Zon LI., Kanki JP., Liu TX., Look AT., Chen Z. (2004). Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of United States of America 101(46):16240-16245. doi:10.1073/pnas.0407241101.
  • Escriva H., Safi R., Hanni C., Langlois MC., Saumitou-Laprade P., Stehelin D., Capron A., Pierce R., Laudet V. (1997). Ligand binding was acquired during evolution of nuclear receptors. Proceedings of the National Academy of Sciences of United States of America 94(13):6803-6808.
  • Hiramitsu M., Shimada Y., Kuroyanagi J., Inoue T., Katagiri T., Zang L., Nishimura Y., Nishimura N., Tanaka T. (2014). Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Scientific Reports 4:3708. doi:10.1038/srep03708.
  • Lu JW., Yang WY., Tsai SM., Lin YM., Chang PH., Chen JR., Wang HD., Wu JL., Jin SL., Yuh CH. (2013). Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish. PLoS ONE 8(10):E76951. doi:10.1371/journal.pone.0076951.
  • Lu JW., Yang WY., Lin YM., Jin SL., Yuh CH. (2013). Hepatitis B virus X antigen and aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish. Acta Histochemica 115(7):728-739. doi:10.1016/j.acthis.2013.02.012.
  • Her GM., Pai WY., Lai CY., Hsieh YW., Pang HW. (2013). Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression. Biochimica et Biophysica Acta- Molecular and Cell Biology of Lipids 1831(6):1037-1051. doi:10.1016/j.bbalip.2013.02.002.
  • Hasumura T., Shimada Y., Kuroyanagi J., Nishimura Y., Meguro S., Takema Y., Tanaka T. (2012). Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. Nutrition & Metabolism (Lond) 9(1):73. doi:10.1186/1743-7075-9-73.
  • McClelland GB., Craig PM., Dhekney K., Dipardo S. (2006). Temperature- and exercise-induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio). The Journal of Physiology 577(2):739-751. doi:10.1113/jphysiol.2006.119032.
  • Ibabe A., Herrero A., Cajaraville MP. (2005). Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes. Toxicology In Vitro 19(6):725-735. doi:10.1016/j.tiv.2005.03.019.
  • Ibabe A., Bilbao E., Cajaraville MP. (2005). Expression of peroxisome proliferator-activated receptors in zebrafish (Danio rerio) depending on gender and developmental stage. Histochemistry and Cell Biology 123(1):75-87. doi:10.1007/s00418-004-0737-2.
  • Fish-it.org
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    Sequence >ENSDART00000152064 Danio rerio PPARalpha-1
    AGCTGCAGTTTGACAGCGGCGGAGGTGCGTCGAGTGTCGGCGGAGGTTATTATGCGTTTGTGGAAATGTTATAAATGATA
    TTTGTCTGCAGTGAGCGGCGGACGGCACCGCTACCGGATCCTGGACGCCCCGAGACGCGATGTTTGACCAGCAGCGGCCG
    GTAAACCTAAAGGCTGATGTGTGACTGGCGCCCGGCCCCTGTCCGCCAGCATGGTAGACATGGAGAATCGCTACCGTCCT
    CCGTCTCCGCTGGACGACTCTGTGCTGGACAGTGCGCTGTTCGTCAGGGGAATGGAGGAGCTGCGGGACATCTCTCAGTC
    CATGGATGAAGACGCTCTCAGCAGCTTCGAGATGACCGAGAACCAGTCCGGTCTGGGCTCTGGATCCGAGAGCTCCACCG
    TGCTGGATGCTCTGACCCCTGCGTCCAGCCCGTCGTCAGGTGTGTACGGTTGCCCGGTGGGTCAGGACGAGTTCACCTCC
    ACCTCTCTGAATCTGGAGTGTCGTGTGTGTTCGGATCGGGCATCAGGATACCACTATGGCGTTCATGCATGTGAGGGCTG
    CAAGGGTTTCTTCCGTCGGACCATTCGGCTCAAACTGGAGTACGATAAGTGTGAACGCCGCTGTAAGATCCAAAAGAAGA
    ACCGAAACAAGTGCCAATACTGTCGATTTCAGAAGTGCCTGTCCGTGGGCATGTCCCACAATGCCATCCGTTTTGGGCGA
    ATGCCACAGTCGGAGAAGCTAAGGTTGAAGGCAGAGATCCTGACAGGAGAACGAGATGTCAAAGATGATCAGAAAACCCT
    GGCCAAGCAGATCTATGAGGCCTACGTCAAGAACTTCAACATGAACAAATCCAAAGCACGAACCATCCTGACGGGAAAGA
    CAAGCACGCCGCCCTTTGTGATCCATGACATGGAGACTCTTCAGCTGGCAGAACAGACGTTTGTGGCCAAGATGATGGGC
    TCTTGCGGAGGTCTGCTGAACAAAGACCCTGAGGTGCGCATATTCCACTGCTGCCAGTGCACTTCAGTCGAGACCGTCAC
    CGAACTGACCGAATTCGCCAAATCTGTGCCCGGATTCTCAAACCTCGACTTAAACGATCAGGTAACGTTACTGAAGTACG
    GTGTCCATGAGGCTCTGTTCGCCATGCTGGCCTCCTGCATGAACAAAGACGGTCTTCTGGTGGCGTACGGCAGTGGCTTC
    ATCACCAGAGAGTTTCTGAAGAGTTTGCGGCGGCCCTTCAGCGACATGATGGAGCCCAAGTTTCAGTTCGCCATGAAGTT
    CAACTCTCTAGAGCTGGACGATAGTGACCTCGCACTGTTTGTCGCTGCCATCATCTGCTGTGGAGATCGTCCCGGTCTGG
    TGAACGTCCCGCATATCGAGCGAATGCAGGAGAGCATTGTTAACGTTCTCCATCTGCACCTGAAGAGCAACCACCCGGAT
    CACGGCTTTCTGTTCCCCAAACTCCTGCAGAAGCTGGTGGACCTGCGTCAGCTGGTGACCGAACATGCACAACTCATACA
    GGAGATCAAGAAAACGGAGGACACGTCGCTGCATCCGCTGCTGCAGGAGATCTACAGAGACATGTACTGA
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    >NM_001161333.1 Danio rerio Peroxisome proliferator-activated receptor alpha 2
    CTCGAGTCAAATCTACAGAGTGGAGAAATCAGGTACAACTTTAGAAAGCTGGACAGCTTCCTCTAACAGACAAAGCTGGA
    AAATGTGATTCTCTGCCAAATGCTGATTTATGACCAGATTCAGCAGGAACAGCTTGTCTACCTTCTACTACTTTTTTTAG
    CACAGATGACACTGCAGCAGAGACTGATGATTGATTCAAATCTTGCCGTGGTCCAGCGCCATGGTAGATATGCCGAGCCT
    CTACAGTCCCTCGTCCCCTCTGGGAGACCCGATTATGTACAGCCCTCTGAGCGGAGAGCTCATTGGTGACATGCAGGTGC
    TGGAGGACATCTCTCAGTCTCTCAGCGACGACACCTTCAACTCCTTTCACATGCTGGACTACCAGAACTGTGACACTGCA
    GTAGACAACTCATCGATATTAGATGTCTTAACTCCGGCGTCTAGTCCGTCCTCAGAAGTGTTCTCAGCCAGCACGGGTCA
    GGACGAGAACTCATCCGGATCTCTCACCCTCGAGTGCCGCGTCTGTGCCGACCGGGCTTCAGGTTTCCACTACGGAGTGC
    ATGCCTGTGAAGGGTGCAAGGGCTTCTTCAGGAGAACCATTCGACTTAAACTGGAGTACGACAAGTGTGAACGCAACTGC
    AAGATCCAGAAGAAGAACCGAAACAAATGTCAATACTGCCGATTCCGCAAGTGCCTTGCAGTGGGCATGTCCCACAACGC
    TATTCGTTTTGGGCGGATACCCCAGTCCGAGAAGCAGCGTCTGAAAGCGGAGCAGGACGTCAGCGGGAAAGAGGAACACA
    AATGTCAGCAGCCGGACATGAGGAGTCTGGCCAGACAGATGCACGAAGCCTACCTCAAACACTTCCACATGAACAAAGCC
    AAAGCACGTGTGTTTCTCACAGGCAAGACCAGCACTCCGCCCTTCGTCATTCACGACATGGACACTCTCCAGCACGCAGA
    GAAGAAACTAGTCACCCAGCTGCTGGGTAACGTGGCATCGGGCGACATCTCCACCCTGCAGGAGCGAGAAGTGGAGGCCC
    GGCTCTTCCTTTTCTGCCAGTACGCTTCAGTGGCCACGGTCACAGAGCTGACGGAGTATGCCAAGGCCGTGCCAGGCTTC
    GCCGACCTGGACCTCAACGACCAGGTGACGCTGCTGAAATACGGGGTGTACGAGGCGCTGTTCACTCTGCTGGCGTCCTG
    CATGAATAAGGACGGACTGCTGGTGGCTCAAGGCGGAGGCTTCATCACCCGAGAGTTTCTGAAGAGCCTGCGCAAACCCT
    TCAGTGACATGATGGAGCCCAAGTTTCAGTTCGCCATGAAGTTCAACGCTTTAGAGCTGGACGACAGTGACCTGGCGCTG
    TTCGTGGCTGCCATCATCTGCTGTGGAGACCGTCCCGGACTCAGCAACGTGCCACAGATCGAGCGCATCCAGGAGAGCGT
    AATCCACTCTCTGCGGCTCCACCTGACGTCCAACCACCCCGACAACAGCTTGCTGTTCCCAAAACTGCTGCAGAAACTGG
    CCGACCTGCGGCAGCTGGTGACGGAGCACGCGGAGCTGGTGCAGGAGATCAACAAGACAGAAGACGCGTCACTCCACCCG
    CTCCTGCAGGAGATCTACAGAGACATGTACTGAGCTCACACGTATGCATTCGACCAGGAGATAAACAGGAGACCGGCAGT
    AACATGTTTAGGGTGTGCACCTACATCAGGATCATCGTAGGGTACGGCCAGTGTAACGAATAGCCTCATCATAATTGCAC
    TGATCTTTACTAAGGCACTGACCTTTATAAGGAGTAAGCTAGACAAGTGCAATAGATGCTTTCCAAACATACTTAGTATA
    TTCCTGAAAGGTGTCATGAAAAAGAAATACGCACCTTAATGATTCAGGTTTACATGTCAGCAGTAAACGGGAAGCAGTAC
    ATCATTAAAGTAAGTTTTGTTTTTGGCGCTTTTATAAAAGCGGAGCTGCTCCTCTGCTCCATCATAATGTCATATTCGCA
    GGCTGGAGTTGTAGATATGGGAACGTGGCTAACGAAGTGTAACTTTTAGAGTGGTCTGCGTCATACCATACAGTTAAGAC
    GAGAAGGATATAAACGGAAGTGGGAGCCAGCTGTAAGTGTGTGGGTCTTGAGCTCCAAGTGGGCTGTACAAAGCTGGAGT
    TTTGATTTATTTAAAGTTTTGTACATGACACCGAGTTCAATATTGTGCTTTATGAACGTCTGCACCTACCCCAACCATAA
    ACCCAACCTCACAGTAAACTGATGTGTTGTGATGTGTATCTGCTCCACCTACAGTACAGCACCCTGCAAACCACAGTAAC
    CTGATTTGTTTTAGTATCGTCTACTACACCTACTCCAGCTCTAAACCCAACCTCACAGTAACCTGATGTGTTTTAGTAAC
    ATCTACACTTGCTCCACCTAGACCCAATCTCACAGTAACCTGATGTGTTTTATTAATATCTGCTCCACCTACACCAGCTA
    ACCCAAGCTACTTTGGTTTAAATCTGTCCCACTTACAGGTCAACCAACCCACTTACGGTGTAATCCATCCCACTCGGTGG
    TCTCTGGGCTGCAGCGATACCTACTTGATTAATATGGGCAGTTGTTGTTTTATAAAGAATATAGCAGCGGTGTGTGTGTG
    TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
    CGCGTGCGTGTGCACTTGTGCTGTAATCTTGAATCCAAAACAATTGTCCTCTGTTGTCTGATGATGTTTTGAGGGCAGCC
    TGTCAATCACACAAGATCGCAACAAAGGCAAAACAGATCTATCACAATAAAAAAATAAAAAAAAGTATGACTGCATATTT
    TGATAAAGAATAACCTTTGCAACTGGTAAAGAAGTGTGCTGTTTATAGAAAGAATTTGTAATGATAAATGAACGTCATTC
    ATGTTGAACAATTGCCATCCACAAATCGTGTCCTGTGGCCTCATGGAATCGTAAAGAGTCGATTGTGTTGACATTTGACA
    ATCTCAACTGAAATAGCAGCTGCAGTTTGATCATTGTGAATGAAAGTGTACTACTTTTATAAATGTCCTATGTTGTAGGG
    TTATGGAGAGGGGTCTGGGAGCAGACCTGGTGCAGTGCAATCTGAGCTGCATCCAATGCTTTGTAATGCACACCCCTAAC
    CCCACCCCTCACAGTGACGCGAGCAGCTCCATTGAGCGCATTGTGTCTGATATTGCATGAGCGAGATATGCAATCTCAGC
    TTGCATCATCAAGACTGCATCTTGCCTTGCAGACATTCTTTTGCCAAATTAGCACCAGCAATCAGGAGTTAAAGCTTGTG
    AAATGAAAAGTGAGCGTGCTGTAAACGAGGTGATGATCTAGGGTTGAATGTACAGAGATAGCTGTATCAAACAGATGGTC
    GTTGCCTTATTTGAAAGACTTGTACATTGAGCATCATTTGTAAAATGTTTTGTATTATGAAAAGAGTATTGTACATTGTA
    TAGCACTCCAACTGTAATTGTATTGTACAGATGTGTTGACTATGAGAAGTGTAAATGATGGTTTTATTGTGTTTTTGGGA
    GGGGAAAATGTGTTGATTTAAGCATTTAGGGAAATGAAATTTGATTTGGAGAAAACGCTTTGTAGATTTGCAACTTAAAG
    AAACATCTCATCTCA
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    Organism

    GO term(s)

    Gene Expression

    Gene Structure

    Possible Primers

    Phylogeny (Gene Tree)

    Synteny

    Genomic Map Locations

    Paralogs

    Sequencing Methods

    Citations

    Sequence

    Gene Domains

    Molecular Markers


    Data input by M.Iliopoulou
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